Journal: Endocrine-related cancer

Article Title: Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis

doi: 10.1530/ERC-16-0536

Figure Lengend Snippet: Histopathology of the gastrointestinal tract in control and Lgr5+ stem cell specific Pten knockout mice fed either a low fat or high-fat diet

Article Snippet: Given that Pten knockout animals were not examined until 14–15 mo of age, nearly 12 mo after Cre induction, it is unlikely that the lack of observed transformation in these mice was confounded by the reportedly long latency of disease onset in Pten- deficient animals ( Knobbe, et al. 2008 ).

Techniques: Histopathology, Control, Knock-Out